Package: AEenrich
Version: 1.1.1
Title: Adverse Event Enrichment Tests
Type: Package
Description: We extend existing gene enrichment tests to perform
        adverse event enrichment analysis. Unlike the continuous gene
        expression data, adverse event data are counts. Therefore,
        adverse event data has many zeros and ties. We propose two
        enrichment tests. One is a modified Fisher's exact test based
        on pre-selected significant adverse events, while the other is
        based on a modified Kolmogorov-Smirnov statistic. We add
        Covariate adjustment to improve the analysis."Adverse event
        enrichment tests using VAERS" Shuoran Li, Lili Zhao (2020)
        <doi:10.48550/arXiv.2007.02266>.
Authors@R: c(
    person(given = "Shuoran", family = "Li", role = c("aut"), email = "shuoranl@umich.edu"),
    person(given = "Hongfan", family = "Chen", role = c("aut"), email = "chenhf@umich.edu"),
    person(given = "Lili", family = "Zhao", role = c("aut"), email = "zhaolili@med.umich.edu"),
    person(given = "Michael", family = "Kleinsasser", role = c("aut", "cre"), email = "mkleinsa@umich.edu"))
License: GPL-2
Encoding: UTF-8
LazyData: true
Biarch: true
Depends: R (>= 3.5.0)
Imports: dplyr, magrittr, qvalue, doParallel, tidyr, modelr, foreach,
        rlang, utils
biocViews:
URL: https://github.com/umich-biostatistics/AEenrich
BugReports: https://github.com/umich-biostatistics/AEenrich/issues
RoxygenNote: 7.3.3
Roxygen: list(markdown = TRUE)
Suggests: testthat
Config/pak/sysreqs: libicu-dev
Repository: https://umich-biostatistics.r-universe.dev
Date/Publication: 2026-01-22 14:18:13 UTC
RemoteUrl: https://github.com/umich-biostatistics/aeenrich
RemoteRef: HEAD
RemoteSha: 1cfe898bb92fa7502f0ed3ba52bfc914003a8170
NeedsCompilation: no
Packaged: 2026-06-21 06:49:08 UTC; root
Author: Shuoran Li [aut],
  Hongfan Chen [aut],
  Lili Zhao [aut],
  Michael Kleinsasser [aut, cre]
Maintainer: Michael Kleinsasser <mkleinsa@umich.edu>