Package: AEenrich 1.1.0
Michael Kleinsasser
AEenrich: Adverse Event Enrichment Tests
We extend existing gene enrichment tests to perform adverse event enrichment analysis. Unlike the continuous gene expression data, adverse event data are counts. Therefore, adverse event data has many zeros and ties. We propose two enrichment tests. One is a modified Fisher's exact test based on pre-selected significant adverse events, while the other is based on a modified Kolmogorov-Smirnov statistic. We add Covariate adjustment to improve the analysis."Adverse event enrichment tests using VAERS" Shuoran Li, Lili Zhao (2020) <arxiv:2007.02266>.
Authors:
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AEenrich.pdf |AEenrich.html✨
AEenrich/json (API)
| # Install 'AEenrich' in R: |
| install.packages('AEenrich', repos = c('https://umich-biostatistics.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/umich-biostatistics/aeenrich/issues
Last updated 2 years agofrom:78580f863a. Checks:1 OK, 7 NOTE. Indexed: yes.
| Target | Result | Latest binary |
|---|---|---|
| Doc / Vignettes | OK | Feb 13 2025 |
| R-4.5-win | NOTE | Feb 13 2025 |
| R-4.5-mac | NOTE | Feb 13 2025 |
| R-4.5-linux | NOTE | Feb 13 2025 |
| R-4.4-win | NOTE | Feb 13 2025 |
| R-4.4-mac | NOTE | Feb 13 2025 |
| R-4.3-win | NOTE | Feb 13 2025 |
| R-4.3-mac | NOTE | Feb 13 2025 |
Exports:count_casesenrich
Dependencies:backportsbroomclicodetoolscolorspacecpp11doParalleldplyrfansifarverforeachgenericsggplot2gluegtableisobanditeratorslabelinglatticelifecyclemagrittrMASSMatrixmgcvmodelrmunsellnlmepillarpkgconfigplyrpurrrqvalueR6RColorBrewerRcppreshape2rlangscalesstringistringrtibbletidyrtidyselectutf8vctrsviridisLitewithr
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| AEenrich: Adverse Event Enrichment Tests | AEenrich-package AEenrich |
| Convert data on the report level to aggregated data. | count_cases |
| Covid Vaccine Adverse Event Data | covid1 |
| Covid Vaccine Adverse Event Data | covid2 |
| Perform Adverse Event Enrichment Tests | enrich |
| Group Structure Data | group |
