SynDI - Synthetic Data Integration

Regression inference for multiple populations by integrating summary-level data using stacked imputations. Gu, T., Taylor, J.M.G. and Mukherjee, B. (2021) A synthetic data integration framework to leverage external summary-level information from heterogeneous populations <arXiv:2106.06835>.

Last updated 3 years ago

4.00 score 1 stars 7 scripts 155 downloads

AEenrich - Adverse Event Enrichment Tests

We extend existing gene enrichment tests to perform adverse event enrichment analysis. Unlike the continuous gene expression data, adverse event data are counts. Therefore, adverse event data has many zeros and ties. We propose two enrichment tests. One is a modified Fisher's exact test based on pre-selected significant adverse events, while the other is based on a modified Kolmogorov-Smirnov statistic. We add Covariate adjustment to improve the analysis."Adverse event enrichment tests using VAERS" Shuoran Li, Lili Zhao (2020) <arXiv:2007.02266>.

Last updated 2 years ago

3.48 score 3 stars 1 scripts 280 downloads

PPMR - Probabilistic Two Sample Mendelian Randomization

Efficient statistical inference of two-sample MR (Mendelian Randomization) analysis. It can account for the correlated instruments and the horizontal pleiotropy, and can provide the accurate estimates of both causal effect and horizontal pleiotropy effect as well as the two corresponding p-values. There are two main functions in the 'PPMR' package. One is PMR_individual() for individual level data, the other is PMR_summary() for summary data.

Last updated 5 years ago

3.28 score 2 stars 19 scripts 116 downloads

qif - Quadratic Inference Function

Developed to perform the estimation and inference for regression coefficient parameters in longitudinal marginal models using the method of quadratic inference functions. Like generalized estimating equations, this method is also a quasi-likelihood inference method. It has been showed that the method gives consistent estimators of the regression coefficients even if the correlation structure is misspecified, and it is more efficient than GEE when the correlation structure is misspecified. Based on Qu, A., Lindsay, B.G. and Li, B. (2000) <doi:10.1093/biomet/87.4.823>.

Last updated 5 years ago

3.18 score 1 packages 2 scripts 108 downloads

SEIRfansy - Extended Susceptible-Exposed-Infected-Recovery Model

Extended Susceptible-Exposed-Infected-Recovery Model for handling high false negative rate and symptom based administration of diagnostic tests. <doi:10.1101/2020.09.24.20200238>.

Last updated 3 years ago

3.00 score 2 stars 3 scripts 199 downloads

lcra - Bayesian Joint Latent Class and Regression Models

For fitting Bayesian joint latent class and regression models using Gibbs sampling. See the documentation for the model. The technical details of the model implemented here are described in Elliott, Michael R., Zhao, Zhangchen, Mukherjee, Bhramar, Kanaya, Alka, Needham, Belinda L., "Methods to account for uncertainty in latent class assignments when using latent classes as predictors in regression models, with application to acculturation strategy measures" (2020) In press at Epidemiology <doi:10.1097/EDE.0000000000001139>.

Last updated 9 months ago

2.70 score 2 scripts 223 downloads

MetaIntegration - Ensemble Meta-Inference Framework

An ensemble meta-inference framework to integrate multiple regression models into a current study. Gu, T., Taylor, J.M.G. and Mukherjee, B. (2021) <arXiv:2010.09971>. A meta-analysis framework along with two weighted estimators as the ensemble of empirical Bayes estimators, which combines the estimates from the different external models. The proposed framework is flexible and robust in the ways that (i) it is capable of incorporating external models that use a slightly different set of covariates; (ii) it is able to identify the most relevant external information and diminish the influence of information that is less compatible with the internal data; and (iii) it nicely balances the bias-variance trade-off while preserving the most efficiency gain. The proposed estimators are more efficient than the naive analysis of the internal data and other naive combinations of external estimators.

Last updated 3 years ago

2.70 score 1 stars 1 scripts 174 downloads

FEprovideR - Fixed Effects Logistic Model with High-Dimensional Parameters

A structured profile likelihood algorithm for the logistic fixed effects model and an approximate expectation maximization (EM) algorithm for the logistic mixed effects model. Based on He, K., Kalbfleisch, J.D., Li, Y. and Li, Y. (2013) <doi:10.1007/s10985-013-9264-6>.

Last updated 5 years ago

2.70 score 1 stars 1 scripts 142 downloads